Sunday, 29 December 2013

Who Needs CGH Embryo Testing?

Who Needs CGH Embryo Testing?

When I treat infertility problems, there is an obvious need of tools and techniques. Modern medical science brings some of the best methods to understand, analyze and correct fundamental problems that were not possible earlier.

Transfer of embryo is a critical step in the treatment of infertility and testing procedures like Comparative Genomic Hybridization (CGH) makes it possible to increase the possibility of success dramatically. We call this test a game changer in the history of infertility treatment.

What is CGH embryo testing?

CGH embryo testing is an effective technique to indentify the most competent and strong embryo based on chromosome testing.

A typical human genome contains 23 pairs or 46 individual chromosomes. If an embryo doesn’t contain these many chromosomes, then we call it an incompetent embryo that can’t produce successful pregnancy.  We call them aneuploid embryos. Most of the embryos will not reach to the stage of blastocyst. If some incompetent cases reach to the stage of blastocyst, then they will not get attached to the wall of the uterus. The pregnancy will get terminated in the first trimester.  In very rare cases, the pregnancy will continue with fundamental genetic problems.

To make the problem further complicated, it is not possible to find the difference between an incompetent embryo and a competent embryo by the conventional methods.

CGH Embryo testing, the effective tool
Experts say that the competency of embryo does not depend on the quality of the sperm, but on the egg.  A competent embryo will result in a live birth almost 80% of the times, provided all other factors like internal environment of the uterus, age, overall health  etc.

Since it is clear that competent embryos result in higher chances of pregnancy, we recommend doing CGH Embryo testing for such cases.

With respect to various research and studies, I emphasize CGH Embryo testing in the following scenario:
•    Female partners suffering from PCOS, it is recommended undergoing CHH embryo testing because higher percentage of eggs are problematic in such case.
•    In case of known disorders of chromosomes, I recommend it.
•    In case of women with old age (usually more than 35) will have to undergo this test to ensure higher pregnancy rate.  The chances of success in such case are relatively low and CGH testing will eliminate one major possibility of failure.
•    Cases of unexplained IVF failures or unexplained termination of pregnancy.
•    Older women with a decreasing trend of ovarian reserve must go for this test to ensure higher chances of pregnancy.
•    Women with genetic problems.
It is quite clear that CGH Embryo testing is the paramount technique of chromosomal testing. Although there have been new techniques like Polymerase Chain Reaction (PCR) emerging on the horizon, but it will take some time for credibility establishment of these methods. CGH has been a proven method with fantastic results.

Modern tools help us in identifying typical factors that cause infertility problems. With the help of such modern tools, we are able to bring happiness in the life of an infertile couple!

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