Sunday, 29 September 2013

Recurrent implantation failure, the devastating problem

Recurrent implantation failure, the devastating problem

The couple was not able to control their emotions of happiness and joy after looking at the report placed on the top of my neatly managed table. It was a positive report showing successful implantation of the embryo confirming the successful pregnancy. It was certainly a moment to celebrate and it becomes further special after a series of unsuccessful In Vitro Fertilization and discontinued pregnancy attempts. The time was surely tough for the couple and me as well.

We had been waiting so long for this good news and tried effortlessly to achieve success. The case was unique. The follicle development was normal, fertilization of the eggs was OK, development of the embryo was fantastic, endometrial thickness was just perfect; but still embryo implantation was failed! Not even once or twice, but for multiple times. However, the series of unsuccessful attempts was over and the couple got the biggest news of the life!

The unknown reasons of recurrent implantation attempts

It is certainly very disappointing to hear about the unsuccessful implantation after a series of painful procedures and emotional ups and downs. There are efforts of the couple, the infertility expert, the technicians and so many other people that go vein.

Why does it happen? Well, it is the fact of the matter that human endometrial (the inner lining of the uterus) is the biggest mystery in spite of extensive research and studies. It is the most crucial part in the human reproduction system.  It undergoes multiple changes and they are triggered by the hormonal secretions in the female body. The estrogen and the progesterone are the two most vital hormones that balance the entire activity. These hormones decide a unique characteristic of the endometrial lining and that it the receptiveness for fertilized egg. According to some experts there is a particular timeframe when the lining is maximum receptive, the so-called window of implantation!

There has been extensive research in the field of endometrial lining and their receptiveness. Studies indicate that there are hundreds of molecular signals known as biological markers that control the receptiveness. There is a certain period when the markers that support for implantation are at the peak and that is what window of implantation. The window is not fixed and it gets shifted to the earlier or later timeframe. Therefore, it is very difficult to determine the most feasible moment to attempt implantation.

The way out

Infertility experts work hard to achieve successful pregnancy and therefore, analyze the past attempts that were failed. It gives a fair idea about the peak window. Since it is based on the analysis pertaining to the specific case and not on the basis of some theoretical calculation, hence it is much accurate. Implanting the embryo after determining the best window, there are better chances of the success.

Recurrent implantation failures give too much stress and frustration to the entire team and therefore, it is better to spend some time in analyzing about the peak time and then trying for the embryo implantation.


  1. Thank you for share. I had had two failed ivf treatments and was wondering if there is anything else I can be doing to improve my chances. Stricter diet? More exercise? I am really open to any ideas. Thanks :)

  2. Implantation failure can be divided into three areas.

    Problems with the embryos
    Problems with "host" uterus.
    Problems in the interaction between embryo and uterus. Failure to achieve a pregnancy following 2-3 IVF cycles in which reasonably good [ high grade embryos] embryos were transferred is termed as implantation failure. Embryonic loss which occurs repeatedly after Assisted Reproduction may be attributed to many factors.