Wednesday, 15 May 2013

Pre-implantation Genetic Diagnose

Pre-implantation Genetic Diagnose: A technique to ensure healthy babies

Among the cases of infertility problems, I would say the most difficult cases are those where there are some genetic problems. Every case puts a different challenge in front of us as infertility experts because the root cause of infertility is different in every case. Genetic disorders place a separate challenge because they may cause serious problems in the babies that take birth after the treatment cycle. My team and I struggle hard and the couple also put their best efforts to let a conception happen. Everything go vein if there are genetic disorders in the baby. There are cases when couples face recurrent miscarriages, continuous failure of IVF retries or cases where earlier babies born with genetic disorders like ‘down syndrome’.

What is PGD?
Pre-implantation Genetic Diagnosis or PGD is a special technique used by us to do genetic profiling of the embryo or Oocyte. They are used when couples don’t want to carry forward to the next generation.

We use various Assisted Reproductive Techniques that help in making the fertilization successful. All these techniques ultimately result in a successful pregnancy. PGD helps in identifying and curing the genetic disorders in the baby before the birth. It is an appendage process to ensure birth of healthy babies.

Who are the best candidates of PGD?
I recommend PGD only in the cases where it is really required. It is neither an essential part of the entire process nor it is a generic process. The couples that get benefited by it the most are:
a) Couples with a history of multiple miscarriages or habitual miscarriages.
b) Couples with a family history of genetic cases like Thalassemia, hemophilia, single gene disorder and chromosome translocations, etc.
c) Couples where the female has to undergo multiple abnormal terminations, either forcible or automatic.
d) Couples where the male partner is facing male infertility issues.

1 comment:

  1. PGD may be used if one or both of the parents have a known genetic abnormality, as the embryos are put through a panel of tests looking for various common chromosome abnormalities. As a result, only normal embryos are transferred to the uterus for implantation.

    PGD Preimplantation Genetic Diagnosis